REAL-WORLD EVIDENCE OF STAGE ASSOCIATED ENDOMETRIOSIS-INDUCED OVARIAN FAILURE
نویسندگان
چکیده
Evaluation of real-world evidence for endometriosis-induced ovarian failure. Patient diagnoses and first cycle AMH, BAFC, age were extracted from electronic medical records patients undergoing ovulatory induction with or without IUI autologous IVF cycles at 11 fertility centers in the Unites States 2002-2019. The available cohort each analysis was classified by stage as Endo1, Endo2, Endo3, Endo4, EndoUnspecified, NonEndo (AMH: N=210, 390, 373, 354, 56322; BAFC: N=570, 1117, 866, 901, 869, 107262; Oocytes retrieved: N=102, 181, 182, 306, 162, 18536). outcomes AMH BAFC modeled using a Gaussian family generalized linear model (GLM) covariates endometriosis stage; oocytes retrieved negative binomial GLM age, covariates. models found that is significantly associated decreased levels reserve markers after controlling stage-dependent manner (p < 0.0001):Tabled 1DiagnosisPercent Decrease Relative to nonEndo (95% Confidence Interval)BAFCAMHEndo1-16.1% (-21.1, -10.6)-18.4% (-31.4, -2.9)Endo2-19.8% (-23.5, -15.9)-25.2% (-35.1, -13.7)Endo3-25.2% (-29.4, -20.8)-37.3% (-47.5, -25.2)Endo4-33.6% (-37.7, -29.4)-42.9% (-51.8, -32.3)EndoUnspecified-20.2% (-24.3, -15.9)-39.6% (-49.3, -28.1) Open table new tab Endometriosis has been response stimulation poorer outcomes, however it not evaluated whether this primarily consequence impact on reserve. We when patient diagnosis EndoUnspecified be retrieved. Furthermore, metrics association oocyte no longer significant. detrimental effects are severity disease, quantity being primary driver reduced observed endometriosis.
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: ['0015-0282', '1556-5653']
DOI: https://doi.org/10.1016/j.fertnstert.2021.07.556